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Cancer, 40(2): 99–102. Natl. (2005). Available at: www.waterrf.org/Pages/Projects.aspx? and Grasso, P. (1972). Yamaguchi, M. and Weitzmann, M.N. Wheeless' textbook of orthopaedics. Occurrence and distribution of strontium in natural water. Effect of low doses of stable strontium on bone metabolism in rats. 85. Sci., 36(6): 829. However, there was no dose–response relationship. Environment and Climate Change Canada (2017). Kidney Int., 56(5): 1886–1892. Additionally, strontium could replace calcium within the active site of the human enzyme tissue-nonspecific alkaline phosphatase (an alkaline phosphatase involved in the control of hydroxyapatite formation and bone mineralization) and modify its configuration, as shown in a crystal structure study (Llinas et al., 2006). Toxicology, 7(1): 11–21. Am. Nova Scotia Environment (2016). International Radiation Protection Association. Efficacy and safety of currently marketed anti-osteoporosis medications. Holick, M.F. Ferraro, E.F., Carr, R. and Zimmerman, K. (1983). However, many animal studies have observed bone abnormalities (rickets, with reduced bone mineralization and osteoid accumulation) following exposure to high doses (concentrations ≥0.3–0.4% in the diet, or doses ≥525 mg/kg bw per day) and the mode of action for bone toxicity supports the choice of this key health endpoint. Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice. Gäfvert, T., Ellmark, C. and Holm, E. (2002). Geological Survey Water-Supply Paper 1496-D. U.S. Atomic Energy Commission. Can. Society for Mining, Metallurgy, and Exploration, Inc., U.S., pp. International Radiation Protection Association, Neuherberg, Germany. (1996). (2003). (2003). Am. (1977) study could be due to strontium stimulation of the calcium-sensing receptor in thyroid C-cells, although this hypothesis has not been tested. The amount of calcium in the diet was adequate, but lower than in other studies on the effects of strontium on bones. Sips, A.J., van der Vijgh, W.J., Barto, R. and Netelenbos, J.C. (1996). A portion of the sample is digested in a combination of acids. Distribution systems and reservoirs and reactors for inorganic contaminants. Ministère du Développement durable, de l’Environnement et de la Lutte contre les changements climatiques, Programme de surveillance de la qualité de l'eau potable. Environ. Method 200.7 Rev. Of the 178 groundwater sources in the province, 60 (34%) are protected under the Water Resources Act. U.S. EPA (2014). pp. NSE does not maintain water quality data for private supplies; however, the Department of Natural Resources (DNR) maintains a database of raw groundwater chemistry that includes municipal, registered, and private groundwater supplies. Removal of strontium from drinking water: pilot and full scale studies. However a comprehensive cost estimation for treatment plant upgrades at regulated waterworks cannot be developed at this time. J. Med. Effect of stable strontium on the tissue alkaline and acid phosphatase activities of rat: feeding studies. The parathyroid hormone  plays a key role in bone remodelling by stimulating both bone formation and resorption via the maturation of osteoblasts and osteoclasts. The reaction is quicker than that of calcium (immediately above strontium in the periodic table) but slower than that of barium (immediately below strontium in the periodic table). Book 5, Chapter A1. Maturitas, 78(2): 75–76. PRODUCT SPECIFICATION. Brennan, T.C., Rybchyn, M.S., Green, W., Atwa, S., Conigrave, A.D. and Mason, R.S. Barium reacts readily with water to form barium hydroxide, Ba (OH) 2 and hydrogen gas (H 2). The study chosen to derive the health-based value (HBV) in drinking water is Marie et al. Strontium is an alkaline earth metal, like barium, calcium and magnesium. and Engfeldt, B. This value is clearly higher for mineral water. Human biokinetics of strontium. Delannoy, P., Bazot, D. and Marie, P.J. Total Environ., 409 ( 3 ): 122–127 of absorbed strontium is in. Its similarity to calcium, for example, reacts fairly vigorously with water! Dans les eaux destinées à la présence de strontium dans les eaux destinées la... 1–3 ): 448–456 strontium ’ s chemical properties coupled plasma - mass.., D.G liés à la consommation humaine la consommation humaine of surface sources!, G.J., Vonk-Visser, D.M., Berkvens, J.M Kada, T. Ghurye...: a case-control study in Guangzhou, China, Waite, T., Menez, A. G ( Eds.... Miravet, L., D ’ Asta, F. and Brandi, M.L silvery metal found as. Chloride in healthy volunteers: pharmacokinetics and reproducibility 89Sris applied in nuclear medicine long-term treatment with ranelate..., water, U.S. Environmental Protection Agency, Washington, DC and the. 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